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ZUBRIN
(tepoxalin)
 
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 ALL of this information was copied/pasted directly from the FDA/CVM ADE [adverse drug event] reports; the only changes made are that the symptoms/conditions caused by and/or associated with the administration of ZUBRIN are alphabetized and the addition of medical terminology definitions from the MedlinePlus medical dictionary on-line at: http://www.nlm.nih.gov/medlineplus/mplusdictionary.html
 

Zubrin (tepoxalin) is made by Schering-Plough and is advertised as "the only dual-pathway canine NSAID".
 
Zubrin website for vets: http://www.zubrinus.com/default.aspx?pageid=112
Zubrin website for pet owners: http://www.zubrin.com/asp/login.asp requires that you must open an account in order to access any pet owner information on this NSAID/drug.

 
FDA/CVM ADE reports: http://www.governmentguide.com/govsite.adp?bread=*Main&url=http%3A//www.governmentguide.com/ams/clickThruRedirect.adp%3F55076483%2C16920155%2Chttp%3A//www.fda.gov
 
FDA/CVM Reports NOTE:  site address (4/22/05):  
 
ZUBRIN  (tepoxalin)
 
ORAL, DOG - March 1, 2005


Reviews:   406
Treated:   469
Reacted:   440
Died:           60 (14.778%)
 
NOTE: for those interested in "How to Read Lab Tests", visit:  http://home.gci.net/~divs/disease/lab_tests.html#rbc 
 
AGGRESSION
ANAPHYLAXIS/TOID - 1) Sorry, the term anaphylaxis/toid is not in the dictionary.  2) ANAPHYLAXIS <pharmacology>As opposed to prophylaxis. A system or treatment that leads to damaging effects on the organism. <immunology> Now reserved for those inflammatory reactions resulting from combination of a soluble antigen with IgE bound to a mast cell that leads to degranulation of the mast cell and release of histamine and histamine like substances, causing localised or global immune reponses. Results in an acute allergic reaction with shortness of breath, rash, wheezing, hypotension. ANAPHYLACTIC SHOCK: an often severe and sometimes fatal systemic reaction in a susceptible individual upon a second exposure to a specific antigen (as wasp venom or penicillin) after previous sensitization that is characterized especially by respiratory symptoms, fainting, itching, and hives
ANEMIA, BLD LOSS
ANEMIA, HEMOLYTIC - Pertaining to autoimmunity. A condition in which an individual's immune system starts reacting against his or her own tissues; anemia caused by excessive destruction (as in chemical poisoning, infection, or sickle-cell anemia) of red blood cells  
ANEMIA, REGEN
ANURIA - nephrology>  The complete suppression of urinary secretion by the kidneys. Synonym: anuresis.
APPREHENSION
ARTHRITIS
BEHAVIOR DISORDER
BITING/CHEWING
BLEEDING:
    BLD (location not specified)
  BLD(ECCHYMOSES) (location not specified) - A small haemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch. 
  BLD, GI
  BLD(HEMATOMA) (location not specified) - Hematoma: a mass of usually clotted blood that forms in a tissue, organ, or body space as a result of a broken blood vessel 
  BLD, INCISION SITE
  BLD, MOUTH/LIP(S)
  BLD, PENIS
  BLD(PETECHIAE) - Petechiae: a minute reddish or purplish spot containing blood that appears in skin or mucous membrane especially in some infectious diseases (as typhoid fever)
BORBORYGMI - a rumbling sound made by the movement of gas in the intestine
COLITIS - inflammation of the colon
COUGHING
CYANOSIS, MUCOUS MEMBR - Cyanosis: a bluish or purplish discoloration (as of skin) due to deficient oxygenation of the blood; mucous membrane: a membrane rich in mucous glands ; specifically : one that lines body passages and cavities which communicate directly or indirectly with the exterior (as the alimentary, respiratory, and genitourinary tracts), that functions in protection, support, nutrient absorption, and secretion of mucus, enzymes, and salts, and that consists of a deep vascular connective-tissue stroma which in many parts of the alimentary canal contains a thin but definite layer of nonstriated muscle and a superficial epithelium which has an underlying basement membrane and varies in kind and thickness but is always soft and smooth and kept lubricated by the secretions of the cells and numerous glands embedded in the membrane -- called also mucosa
CYSTITIS - inflammation of the urinary bladder
DEAFNESS
DEHYDRATION - the process of dehydrating ; especially : an abnormal depletion of body fluids
DIABETES M, POOR REGUL
DIABETES MELLITUS - a variable disorder of carbohydrate metabolism caused by a combination of hereditary and environmental factors and usually characterized by inadequate secretion or utilization of insulin, by excessive urine production, by excessive amounts of sugar in the blood and urine, and by thirst, hunger, and loss of weight
DIARRHEA, MILD
DIARRHEA, MUCOID
DIARRHEA, PROJECTILE
DIARRHEA, SEVERE
DIARRHEA, WATERY
DIFFICULTY RISING
DILITATION, ESOPHAGUS
- No entries found that match DILITATION. One entry found for dilatation: the condition of being stretched beyond normal dimensions especially as a result of overwork or disease or of abnormal relaxation <dilatation of the heart> <dilatation of the stomach
DYSPNEA - difficult or labored respiration
DYSURIA - difficult or painful discharge of urine

ECCHYMOSIS, INCISION SITE - the escape of blood into the tissues from ruptured blood vessels marked by a livid black-and-blue or purple spot or area ; also : the discoloration so caused
EPISTAXIS
- NOSEBLEED an attack of bleeding from the nose -- called also epistaxis
EYES:
        DISCHARGE, EYE(S)/LID(S)
    KERATOCONJUNCTIVITIS S - combined inflammation of the cornea and conjunctiva; refer to dry eye:  a condition associated with inadequate tear production and marked by redness of the conjunctiva, by itching and burning of the eye, and usually by filaments of desquamated epithelial cells adhering to the cornea -- called also keratoconjunctivitis sicca 
    MYDRIASIS - excessive or prolonged dilation of the pupil of the eye 
    NYSTAGMUS
- a rapid involuntary oscillation of the eyeballs occurring normally with dizziness during and after bodily rotation or abnormally after injuries (as to the cerebellum or the vestibule of the ear) 
    OPACITY, CORNEA(S)
    SQUINTING
    ULCER(S), CORNEA(S)
FEVER, BODY
GASTROENTERITIS - inflammation of the lining membrane of the stomach and the intestines
HEAD BOBBING
HEART:
    BRADYCARDIA - relatively slow heart action whether physiological or pathological 
    PULSE THREADY
    TACHYCARDIA
- relatively rapid heart action whether physiological (as after exercise) or pathological
HYPERACTIVITY
HYPERESTHESIA
- unusual or pathological sensitivity of the skin or of a particular sense to stimulation <tactile hyperesthesia of the leg>
HYPERPNEA - abnormally rapid or deep breathing
HYPERSALIVATION - excessive salivation
HYPOSMIA - impairment of the sense of smell
ICTERUS, BODY
- JAUNDICE 1 : a yellowish pigmentation of the skin, tissues, and certain body fluids caused by the deposition of bile pigments that follows interference with normal production and discharge of bile (as in certain liver diseases) or excessive breakdown of red blood cells (as after internal hemorrhage or in various hemolytic states) -- called also icterus  2 : any disease or abnormal condition (as hepatitis A or leptospirosis) that is characterized by jaundice -- called also icterus - hemolytic jaundice: a condition characterized by excessive destruction of red blood cells accompanied by jaundice
IMMUNE DISORDER
- No entries found that match IMMUNE DISORDER
IMPROVEMENT, UNEXPECT (just in case you still think veterinarians don't know what NSAIDs do)
INCONTINENCE -inability of the body to control the evacuative functions 
INCONTINENCE, FECAL
INEFFECT, OTHER DRUG(S
INFECTION, URINARY TRA
JERKING
KIDNEY DISORDER
KIDNEY FAILURE
LAB TESTS/BLOOD:
    ALBUMIN LO, BLD
    AMYLASE HI, BLD
    BANDS HI, BLD
    BILIRUBIN(TOT) HI, BLD
    CA HI, BLD
    CHLORIDE LO, BLD
    CHOLESTEROL HI, BLD
    COAGULATION DISORDER
    GLOBULIN LO, BLD
    GLUCOSE HI, BLD
    K LO, BLD
    KIDNEY VALUES HI, BLD
    LIPASE HI, BLD
    LIVER ENZYMES HI, BLD
    LYMPHS LO, BLD
    NA LO, BLD
    P HI, BLD
    PLATELETS LO, BLD
    PROTEIN(TOT) LO, BLD
    SEGS HI, BLD
    SGOT/AST HI, BLD  
    TRIGLYCERIDES HI, BLD
LAB TESTS/URINE:
    ABN COLOR, URINE
    CRYSTALS, URINE
    GLUCOSE, URINE
    HEMOGLOBIN, URINE
    SPEC GRAVITY LO, URINE
LIVER DISORDER
LOCOMOTION DISORDER
MORIBUND
- being in the state of dying : approaching death <in the moribund patient deepening stupor and coma are the usual preludes to death
NAUSEA
NEOPLASM (location not specified): a new growth of tissue serving no physiological function :
TUMOR -- compare CANCER 1
NEOPLASM, BONE
NEUROLOGICAL DISORDER - of or relating to neurology; neurology: the scientific study of the nervous system especially in respect to its structure, functions, and abnormalities  
NOCTURIA - urination at night especially when excessive -- called also nycturia
ODOR
PACING
PAIN
PAIN, ABDOMEN
PALLOR - deficiency of color especially of the face : PALENESS <patients in hemorrhagic shock may exhibit extreme pallor -- Scientific American Medicine>
PALLOR, MUCOUS MEMBRAN
PANCREATITIS - inflammation of the pancreas
PARESIS
- 1 : slight or partial paralysis 2 : GENERAL PARESIS One entry found for general paresis: insanity caused by syphilitic alteration of the brain that leads to dementia and paralysis -- called also dementia paralytica, general paralysis of the insane 
POLYPHAGIA - excessive appetite or eating
POLYPNEA - rapid or panting respiration
POLYURIA - excessive secretion of urine
PR-BLADDER, LESION(S)
PR-LIVER, LESION(S)
PR-LUNG(S), LESION(S)
PR-LYMPH NODE(S), LESI
PR-MEDULLA, LESION(S)
PR-MENINGES, LESION(S)
PR-MULT SITES, BLD
PR-PANCREAS, LESION(S)
PR-SM INTEST, LESION(S
PR-SPINAL CORD, LESION
PR-STOMACH, LESION(S)
PRURITIS
- No entries found that match PRURITIS. Puritus: localized or generalized itching due to irritation of sensory nerve endings from organic or psychogenic causes : ITCH
RADIOGRAPH(S) ABN
RELUCTANT TO MOVE
RESPIRATORY DISORDER
SHAKING
SHOCK
- 1 : a sudden or violent disturbance in the mental or emotional faculties; 2 : a state of profound depression of the vital processes of the body that is characterized by pallor, rapid but weak pulse, rapid and shallow respiration, reduced total blood volume, and low blood pressure and that is caused usually by severe especially crushing injuries, hemorrhage, burns, or major surgery <the patient was admitted to the hospital in shock>; 3 : sudden stimulation of the nerves or convulsive contraction of the muscles accompanied by a feeling of concussion that is caused by the discharge through the animal body of electricity from a charged source. ANAPHYLACTIC SHOCK: an often severe and sometimes fatal systemic reaction in a susceptible individual upon a second exposure to a specific antigen (as wasp venom or penicillin) after previous sensitization that is characterized especially by respiratory symptoms, fainting, itching, and hives
SKIN/HAIR:
        ALOPECIA - loss of hair, wool, or feathers : BALDNESS 
    CONGESTION, SKIN - Congestion: an excessive accumulation especially of blood in the blood vessels of an organ or part whether natural or artificially induced (as for therapeutic purpose) 
    DERMATITIS, MOIST -  Dermatitis: inflammation of the skin -- called also dermitis 
    ERUPTION(S)
- 1 : an act, process, or instance of erupting <the eruption of the tooth from the gum> ; specifically : the breaking out of an exanthem or enanthem on the skin or mucous membrane (as in measles) 2 : something produced by an act or process of erupting: as a : the condition of the skin or mucous membrane caused by erupting b : one of the lesions (as a pustule) constituting this condition 
      HAIR, ABN COLOR
    HAIR, SHEDDING
    HYPERPIGMENTATION, SKI - excess pigmentation in a bodily part or tissue (as the skin) <brown hyperpigmentation with accentuation in sun-exposed areas 
    LEUKODERMA - a skin abnormality that is characterized by a usually congenital lack of pigment in spots or bands and produces a patchy whiteness 
    MASS, SKIN
    PUSTULE(S)
- 1 : a small circumscribed elevation of the skin containing pus and having an inflamed base 2 : a small often distinctively colored elevation or spot resembling a blister or pimple 
    RASH - an eruption on the body typically with little or no elevation above the surface 
    SCALE(S), SKIN
-a small thin dry lamina shed (as in many skin diseases) from the skin
    SEBORRHEA - abnormally increased secretion and discharge of sebum producing an oily appearance of the skin and the formation of greasy scales
    SKIN, DRY
    SKIN, NECROSIS - Necrosis: death of living tissue ; specifically : death of a portion of tissue differentially affected by local injury (as loss of blood supply, corrosion, burning, or the local lesion of a disease)
    SKIN, SCAB(S)
SOUND ABN, RESPIRATORY
STOMATITIS - any of numerous inflammatory diseases of the mouth having various causes (as mechanical trauma, irritants, allergy, vitamin deficiency, or infection) <erosive stomatitis>
STOOL ABN
STOOL, MUCOID
STUPOR - a condition of greatly dulled or completely suspended sense or sensibility <a drunken stupor> ; specifically : a chiefly mental condition marked by absence of spontaneous movement, greatly diminished responsiveness to stimulation, and usually impaired consciousness
SWELLING, HEAD/FACE
SWELLING, LIMB(S)
ULCER(S), GI
ULCER(S), MOUTH/LIP(S)
ULCER(S), STOMACH
ULCER(S), TONGUE
UNPALATABLE
UNPALATABLE, WON'T EAT
URINATION
URTICARIA
- HIVES an allergic disorder marked by raised edematous patches of skin or mucous membrane and usually by intense itching and caused by contact with a specific precipitating factor (as a food, drug, or inhalant) either externally or internally -- called also urticaria
US ABN
US-LIVER ABN
VASCULITIS - inflammation of a blood or lymph vessel; necrotizing vasculitis: an inflammatory condition of the blood vessels characterized by necrosis of vascular tissue -- called also necrotizing angiitis, systemic necrotizing vasculitis
VOMITING, PROJECTILE
VOMITING, SEVERE
VOMITING, UNPRODUCTIVE
WEIGHT LOSS
XEROSTOMIA - abnormal dryness of the mouth due to insufficient secretions -- called also dry mouth
 
SYMPTOMS/CONDITIONS listings for other NSAIDs [non steroid anti inflammatory drugs are at:
 
RIMADYL: http://rimadyldeth.com/RimadylTRUTH.htm
DERAMAXX: http://rimadyldeath.com/DERAMAXX-TRUTH.htm
METACAM: http://rimadyldeath.com/METACAM-TRUTH.htm 



 

May my beloved partner ROMI rest in peace  - no matter wherever her bits and pieces/frozen carcass may be held hostage.

                            

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