ROMI's Website
 
This is the
 
NSAID's LABORATORY/TESTS
INFORMATION 
 
page.  To return to the main/index page, you may use your "back" browser, or click here:  http://rimadyldeath.com/index.html.
 
The music for this page is "Killing Me Softly".

 
Because a growing number of folks have been asking about what could/should be looked for regarding laboratory testing to determine whether their still living dog has been "damaged" by NSAIDs toxicity, this is a new page that contains RESPONSES on that question from experts who do NOT make money from pet owners as well as the laboratory tests information provided to the FDA/CVM on the ADE [adverse drug event reports] for both RIMADYL and DERAMAXX. 
 
I have been told by several people who have claimed that they are "qualified veterinarians" [but declined to name any specific tests], as well as a number of people who've stated  that their veterinarian has told them that there ARE laboratory tests that can be done to determine whether an individual dog is a good or not a good candidate to receive or continue receiving NSAIDs as well as for "monitoring" system damage levels while on NSAIDs.  From the canine NSAID drug labels that I've found on the Internet, both the FDA/CVM and the drug manufacturers state that laboratory testing should be done PRIOR to prescribing/dispensing NSAIDs and continued monitoring via lab tests as well, but NOWHERE are ANY specific tests mentioned or what laboratory test results might be for EITHER a good or a poor candidate for NSAIDs.
 
As you look at the below laboratory results [in the second section of the page] for both NSAIDs listed here [RIMADYL and DERAMAXX], please notice that there are a LOT of them that say both "high" and "low" as to the findings.  Therefore, it's my opinion that it's just as likely as not, that doing "laboratory tests" to evaluate/monitor NSAID toxicity is more for the purpose of "generating revenue" than for any actual or factual scientific information of value/use to either the pet or the pet owner. 
 
Should there be any "qualified" person(s) who can provide specific information as to what tests will/would determine accurate information as to NSAID toxicity, either for pre-testing or monitoring, I invite them to send me the information and I'll be happy to put it on this page:  GingerLSanchez@aol.com
 
To obtain further GENERAL information on how to read laboratory tests and a chart on "normal values", see: http://home.gci.net/~divs/disease/lab_tests.html#rbc
 

So far, there has been a DEAFENING silence regarding specific accurate tests/results for NSAIDs toxicity, other then the sound of the cash registers:
 
"Business" is booming, along with the pet death/damage toll.


LAB TESTING UPDATE
 
TESTING/MONITORING for NSAIDs damage/reactions
 
For those folks who've heard, believed, were told by practicing veterinarians or have said that they thought testing/monitoring an individual pet could/would accurately predict/anticipate NSAID damage/reactions, you've just been hearing the sound of ca$h registers ! 
 
After sending out more e-mail inquiries than I can even count with the question:
I am hoping that you can tell me whether or not there is such a thing as a SPECIFIC test or panel of tests that would accurately predict how an individual dog would react, either positively OR negatively, to the usage of NSAIDs [non steroid anti inflammatory drugs], and if so what the name of the test(s) is/are as well as any of the aspects regarding post-administration "monitoring" of same. This information is requested for general research only.  Thank you.
 
and hearing nothing but a very deep silence from veterinarians who make money doing "pre-screening/testing/monitoring",  I  have received  responses below:


 
4/12/05
 
Douglas Island Veterinary Services
Attn: "Les"
 
THANK YOU VERY MUCH for responding!  What you say [below] makes absolutely perfect sense, even to a non-medical person such as myself, and I really appreciate the information.
 
Ginger Sanchez
Seattle, WA
 
In a message dated 4/12/05 7:09:06 P.M. Pacific Daylight Time, gauchedvm@gci.net writes:
since some dogs show kidney damage, and some dogs show GI irritation, and some dogs experience liver damage, there's no one test that would predict a dog's response.  a standard chemistry panel  with both liver and kidney tests would tell you if a dog absolutely shouldn't take NSAIDS, but even if all systems were functioning perfectly, some dogs will react negatively.  and you never know about a positive response until you try a drug.
 
don't you wish medicine were easy?  that's why they call it "practicing" and an "art".
 
les
----- Original Message -----
Sent: Monday, April 04, 2005 3:05 PM
Subject: [Norton AntiSpam] Web Site Message/Information Request

4/04/05
 
Douglas Island Veterinary Services
 
I am hoping that you can tell me whether or not there is such a thing as a SPECIFIC test or panel of tests that would accurately predict how an individual dog would react, either positively OR negatively, to the usage of NSAIDs [non steroid anti inflammatory drugs], and if so what the name of the test(s) is/are as well as any of the aspects regarding post-administration "monitoring" of same.  Thank you.
 
Ginger Sanchez
CONTACT: e-Mail ONLY: GingerLSanchez@aol.com
 
 

 
 [4/07/05] from three teaching veterinarians of the Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University at Fort Collins, Colorado:
 
"To answer your question there is no specific test to determine how an animal will react.  Complications we see from NSAIDS is GI ulceration, renal tubular damage and sometimes liver toxicity (thought to be an idiosyncratic reaction).  Dogs with NSAIDS as far as toxicity seems to be variable however dogs are more sensitive to NSAIDS than people and certain ones are quite toxic.  There is also individual variation and toxicity is certainly dose related."
 

At last!  a response from a veterinarian to the question of whether there's a test to determine if an individual dog will have a positive or negative response to useage of NSAIDs:
 
In a message dated 4/4/05 5:11:50 A.M. Pacific Daylight Time, Ginger L Sanchez writes:
4/04/05
 
Dear Dr. Tayman,
 
Thank you very much for your response.
 
Ginger Sanchez
 
 
In a message dated 4/4/05 4:52:04 A.M. Pacific Daylight Time, dtayman@earthlink.net writes:

Answer blow each question-but you should be discussing this with your vet and not me

 


From: GingerLSanchez@aol.com [mailto:GingerLSanchez@aol.com]
Sent: Saturday, April 02, 2005 8:54 AM
To: dtayman@earthlink.net
Subject: Re: Information Request(2)

 4/02/05

 Columbia Animal Hospital

Thank you very much for responding to my initial information request.  As I have absolutely no veterinary training, I apologize in advance for asking more questions and trying to make sure I understand your response.

IF I understand correctly, you "usually perform a profile to evaluate kidney and liver function pre treatment":

QUESTION: what are the criteria used to determine whether or not to do "a profile"? If on the med for over 7 days

QUESTION: is the name of the test "a profile"? Chemistry profile-

QUESTION: does "a profile" accurately predict an individual dog's potential risk/danger of an adverse reaction to receiving NSAIDs [non steroid anti inflammatory drugs]? If findings are abnormal-you pet may be at risk for administration of NSAIDS

Thank you.

Ginger Sanchez

In a message dated 4/2/05 1:31:00 A.M. Pacific Standard Time, dtayman@earthlink.net writes:

We usually perform a profile to evaluate kidney and liver function pre treatment and 2 weeks out into the treatment along with a blood panel every 6 mos -if your pet is on long term use of the anti-inflammatory meds

If short term, we usually do not perform panels


-----Original Message-----
From: GingerLSanchez@aol.com
Sent: Apr 1, 2005 8:49 AM
To: info@petshealth.com
Subject: Information Request

4/01/05

Columbia Animal Hospital

In "surfing the web", I came across your site on laboratory testing: http://www.cah.com/dr_library/labtests.html

 I am wondering if you have or know of any specific test(s) that would accurately predict an individual dog's potential risk/danger of an adverse reaction to receiving NSAIDs [non steroid anti inflammatory drugs]?

Thank you.

Ginger Sanchez

CONTACT: e-Mail ONLY: GingerLSanchez@aol.com

 




RIMADYL: LAB/BLOOD:
    AGRANULOCYTOSIS, BLD  from MedLine: an acute febrile condition marked by severe depression of the granulocyte-producing bone marrow and by prostration, chills, swollen neck, and sore throat sometimes with local ulceration and believed to be basically a response to the side effects of certain drugs of the coal-tar series (as aminopyrine) -- called also agranulocytic angina, granulocytopenia
    A/G RATIO HI, BLD
    A/G RATIO LO, BLD
    ALBUMIN HI, BLD
    AMMONIA HI, BLD
    ANION GAP HI, BLD  
    AMYLASE HI, BLD
    ANEMIA, AUTOIMMUNE HEM from MedLine: Acquired Thrombocytopenia 
    ANEMIA, HEMOLYTIC
    ANEMIA, REGEN
    ANEMIA, SPHERO 
    BANDS HI, BLD
    BASOS HI, BLD
    BILE ACIDS HI, BLD
    BILIRUBIN(DIR) HI, BLD
    BILIRUBIN(IND) HI, BLD
    BLD, ABNORMAL
    BLD, GI
    BLD, SEMEN
    BLD, SQ
    BUN LO, BLD
    CA HI, BLD
    CA LO, BLD
    CA/P RATIO LO, BLD
    CHOLESTEROL HI, BLD
    CO2 HI, BLD
    CO2 LO, BLD
    COAGULATION DISORDER
    CPK HI, BLD
    CHEMISTRY ABN
    CHLORIDE HI, BLD
    CHLORIDE LO, BLD
    CHOLESTEROL LO, BLD
    COOMBS TEST POS  from MedLine: Autoimmune Hemolytic Anemia and Thrombocytopenia: Drugs, vaccines, or infections also can precipitate attacks of hemolytic anemia or thrombocytopenia . . . 
    CREATININE LO, BLD
    CULTURE/TITER DATA ABN
    EOSINOS HI, BLD
    EOSINOS LO, BLD
    FIBRINOGEN HI, BLD
    FIBRINOGEN LO, BLD
    GGT HI, BLD
    GLOBULIN HI, BLD
    GLOBULIN LO, BLD
    GLUCOSE HI, BLD
    GLUCOSE LO, BLD
    HCO3 HI, BLD
    HCO3 LO, BLD HEMATOCHEZIA from MedLine: Decreased red blood cell production
    K HI, BLD
    K LO, BLD 
    KIDNEY VALUES HI, BLD
    LDH HI, BLD
    LIPASE HI, BLD
    LIPIDS HI, BLD 
    LIVER PROFILE HI 
    LYMPHS HI, BLD
    LYMPHS LO, BLD
    MG HI, BLD
    MG LO, BLD 
    MONOS HI, BLD
    MONOS LO, BLD 
    NA HI, BLD
    NA LO, BLD 
    NA:K LO, BLD
    P LO, BLD
    PANCREAS ENZYMES HI, B 
    PLATELETS HI, BLD
    POLYCYTHEMIA
 From MedLine: Polycythemia:  Too many red blood cells.  The opposite of anemia.  Polycythemia formally exists when the hemoglobin, red blood cell (RBC) count, and total RBC volume are all above normal.
    PRESSURE HI, BLD
    PRESSURE LO, BLD
    PR-MULT SITES, BLD
    PROTEIN(TOT) HI, BLD
    PROTEIN(TOT) LO, BLD
    PT PROLONGED, BLD
    PTT PROLONGED, BLD
    RBC ABNORMAL 
    RBC, ANISO
    RBC, MICRO
    RBC, NUCLEATED
    RBC, POLYCHROM
    RETICULOCYTES HI, BLD
    RETICULOCYTES LO, BLD
    SEGS HI, BLD
    SEGS LO, BLD
    THYROID HORMONE(S) HI
    THYROID HORMONE(S) LO
    TRIGLYCERIDES HI, BLD
    URIC ACID HI, BLD
    WBC LO, BLD
 
RIMADYL: LAB/URINE:
    URINE ABN
    ABN COLOR, URINE
    ABN ODOR, URINE
    ACID URINE
    ALKALINE URINE
    ANURIA  Acute renal failure occurs when a major insult to the kidneys results in inability to regulate water and solute balance; this may occur when urine flow is reduced.
    BILIRUBIN, URINE
    CALCULI, URINE 
    CASTS, URINE 
    CLOUDY URINE
    CORT/CREAT HI, URINE
    CRYSTALS, URINE
    CYSTITIS
    DYSURIA from MedicineNet:  Dysuria: Painful or difficult urination. This includes burning on urination. Dysuria is most commonly due to bacterial infection of the urinary tract causing inflammation of the bladder (cystitis) or kidney (pyelonephritis).  There are many other causes of dysuria including irritation from chemicals.
    GLUCOSE, URINE
    HEMOGLOBIN, URINE
    INCONTINENCE, URINARY
    K HI, URINE
    KETONES, URINE
    MICROORANISMS, URINE
    MYOGLOBIN, URINE
    ODOR, URINE
    P HI, URINE
    PROTEIN, URINE
    SEDIMENT, URINE
    SPEC GRAVITY HI, URINE
    SPEC GRAVITY LO, URINE
    UREMIA from MedLine: 1 : accumulation in the blood of constituents normally eliminated in the urine that produces a severe toxic condition and usually occurs in severe kidney disease  2 : the toxic bodily condition associated with uremia
    UROBILINOGEN HI 
    US ABN
    WBC, URINE
 
DERAMAXX: LAB/BLOOD:
    A/G RATIO LO, BLD
    ALBUMIN HI, BLD
    ALBUMIN LO, BLD
    ALK PHOS HI, BLD
    AMYLASE HI, BLD
    ANION GAP HI, BLD
    BANDS HI, BLD
    BASOS HI, BLD
    BILE ACIDS HI, BLD
    BILIRUBIN(DIR) HI, BLD
    BILIRUBIN(TOT) HI, BLD
    BUN HI, BLD
    BUN LO, BLD
    CA HI, BLD
    CA LO, BLD
    CAPILLARY REFILL PROLO
    CHEMISTRY ABN
    CHLORIDE HI, BLD
    CHLORIDE LO, BLD
    CHOLESTEROL HI, BLD
    CHOLESTEROL LO, BLD
    CO2 LO, BLD
    COAGULATION DISORDER
    CPK HI, BLD
    CREATININE HI, BLD
    CULTURE/TITER DATA ABN
    EOSINOS HI, BLD
    EOSINOS LO, BLD
    GGT HI, BLD
    GLOBULIN HI, BLD
    GLOBULIN LO, BLD
    GLUCOSE HI, BLD
    GLUCOSE LO, BLD
    K HI, BLD
    K LO, BLD
    KIDNEY VALUES HI, BLD
    LDH HI, BLD
    LIPASE HI, BLD
    LIVER ENZYMES HI, BLD
    LYMPHS HI, BLD
    LYMPHS LO, BLD
    MG HI, BLD
    MG LO, BLD
    MONOS HI, BLD
    NA HI, BLD
    NA LO, BLD
    NA:K LO, BLD
    P HI, BLD
    P LO, BLD
    PANCREAS ENZYMES HI, B
    PLATELETS HI, BLD
    PLATELETS LO, BLD
    PROTEIN(TOT) HI, BLD
    PROTEIN(TOT) LO, BLD
    PT PROLONGED, BLD
    PTT PROLONGED, BLD
    RBC ABN
    RBC, NUCLEATED
    RETICULOCYTES HI, BLD
    RETICULOCYTES LO, BLD
    SEGS HI, BLD
    SEGS LO, BLD
    SGOT/AST HI, BLD
    SGPT/ALT HI, BLD
    THYROID HORMONE(S) HI
    THYROID HORMONE(S) LO
    TRIGLYCERIDES HI, BLD
    WBC HI, BLD
    WBC LO, BLD
 
DERAMAXX: LAB/URINE:
    ABN COLOR, URINE
    ACID URINE
    ALBUMIN HI, URINE
    ALKALINE URINE
    BILIRUBIN, URINE
    BLD, URINE
    CALCULI, BLADDER
    CASTS, URINE
    CORT/CREAT HI, URINE
    CRYSTALS, URINE
    GLUCOSE, URINE
    HEMOGLOBIN, URINE
    MICROORANISMS, URINE
    PROTEIN, URINE
    SPEC GRAVITY LO, URINE
    WBC, URINE


May my beloved partner ROMI rest in peace  - no matter wherever her bits and pieces/frozen carcass may be held hostage

    

  [what's in YOUR "urn" ?]

http://www.thesqueakywheel.com/complaints/complaint5611.cfm

 

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