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8/15/05
from: http://www.fda.gov/bbs/topics/enforce/2005/ENF00910.html
 
FDA/CVM DERAMAXX RECALL

Enforcement Report

The FDA Enforcement Report is published weekly by the Food and Drug Administration, Department of Health and Human Services. It contains information on actions taken in connection with agency Regulatory activities.

rule

July 27, 2005

PRODUCT
a) Dermaxx™ (deracoxib) 25 mg tablets,
A coxib-class NSAID *For Use in Dogs Only*.
The product is packed in plastic screw top
bottles containing 30 and 90 tablets each.
Recall # V-091-5;
b) Deramaxx (deracoxib) 100 mg tablets,
A coxib-class NSAID *For Use in Dogs Only*.
The product is packed in plastic screw top
bottles containing 90 tablets. Recall # V-092-5
CODE
a) Lot numbers SPT3C001, SPT3C208, SPN3C213 and
SPT3C029;
b) Lot number SPN3C166
RECALLING FIRM/MANUFACTURER

Recalling Firm: Novartis Animal Health US, Inc, Greensboro, NC, by telephone and fax on June 15, 2005, and follow up letter on June 28, 2005.
Manufacturer: Pfizer Pharmaceuticals Llc formally Gd Searle Llc, Caguas, PR. Firm initiated recall is ongoing.
REASON

Product does not meet the finished product assay specifications.
VOLUME OF PRODUCT IN COMMERCE

a) Unknown;
b) 4530 bottles
DISTRIBUTION

CA. GA, and HI

END OF ENFORCEMENT REPORT FOR July 27, 2005


SHORT/BRIEF DERAMAXX CHART
from: http://www.cyberdobes.com/PDF/Deramaxx.pdf [courtesy of: Edward Murray, a pet owner with an interest in pet diabetes and NSAIDs in veterinary
medicine. He can be reached at 
e.murray@vetnsaids.com.]
 
Reported Adverse Drug Reactions
Deramaxx (deracoxib)
Source: Center for Veterinary Medicine, Food and Drug Administration. February 24, 2003.
http://www.fda.gov/cvm/index/ade/ade_web_rpts.htm
 
NOTE:  site address (4/22/05):  
 
 
 
TOTAL DEATHS:             27        25%
 


LONG/DETAILED LIST OF 
 
DERAMAXX
 
CONDITIONS/SYMPTOMS
 

from: http://www.governmentguide.com/govsite.adp?bread=*Main&url=http%3A//www.governmentguide.com/ams/clickThruRedirect.adp%3F55076483%2C16920155%2Chttp%3A//www.fda.gov

 
NOTE: the below information is directly from the FDA/CVM's ADE [adverse drug event] reports.  The only changes made are that the symptoms/conditions caused by and/or associated with DERAMAXX have been alphabetized and medical definitions of the terminology have been provided from either the Merck Veterinary Manual online at: http://www.merckvetmanual.com/mvm/index.jsp or from the Medical Dictionary online at: http://medical-dictionary.com/ and when all else failed, Mirriam-Webster's Dictionary onlinr at: http://www.m-w.com/.
 
February 9, 2005
FDA/CVM ADE Report on DERAMAXX [DERACOXIB]
from:
NOTE:  site address (4/22/05):  

2650 Reviews    2701 Treated    2670 Reacted    601  Died
 
 
ACCIDENTAL EXPOSURE
ADIPSIA  - Absence of thirst or the lack of desire to drink.  
ANA POS - anapophysis - <anatomy> An accessory process in many lumbar vertebrae.
AGGRESSION
ANAPHYLAXIS/TOID - 1) Sorry, the term anaphylaxis/toid is not in the dictionary.  2) ANAPHYLAXIS <pharmacology>As opposed to prophylaxis. A system or treatment that leads to damaging effects on the organism. <immunology> Now reserved for those inflammatory reactions resulting from combination of a soluble antigen with IgE bound to a mast cell that leads to degranulation of the mast cell and release of histamine and histamine like substances, causing localised or global immune reponses. Results in an acute allergic reaction with shortness of breath, rash, wheezing, hypotension.
ANEMIA  <haematology> Too few red blood cells in the bloodstream, resulting in insufficient oxygen to tissues and organs.
ANEMIA, AUTOIMMUNE HEM -  1) Sorry, the term anemia autoimmune is not in the dictionary. 2) immunology>Pertaining to autoimmunity. A condition in which an individual's immune system starts reacting against his or her own tissues.
ANEMIA, HEINZ BODY unstable haemoglobin haemolytic anaemia; Coccoid inclusion bodies resulting from oxidative injury to and precipitation of haemoglobin, seen in the presence of certain abnormal haemoglobins and erythrocytes with enzyme deficiencies.  
ANEMIA, REGEN 
ANEMIA, SPHERO 
ANESTH RECOV PROLONGED
ANOREXIA
- <symptom> The uncontrolled lack or loss of the appetite for food.
ANURIA - <nephrology>  The complete suppression of urinary secretion by the kidneys. Synonym: anuresis.
APLASIA, BONE MARROW - <embryology>  A lack of development of an organ or tissue or of the cellular products from an organ or tissue.
APNEA -  <clinical sign>Cessation of breathing.
APPREHENSION
ARTHRITIS, SEPTIC - <pathology>A pus-forming bacterial infection of a joint space. Symptoms include a hot, swollen, red joint, that is very tender to any attempted movement.
ASCITES - <clinical sign, gastroenterology>An effusion and accumulation of serous fluid in the abdominal cavity. Synonym: abdominal dropsy, peritoneal dropsy, hydroperitonia, hydrops abdominis.
ATAXIA - <neurology> Failure of muscular coordination, irregularity of muscular action.
ATONY, BLADDER - <neurology> A lack of normal tone or strength.
ATROPHY, MUSCLE(S)
- <pathology> A wasting away, a diminution in the size of a cell, tissue, organ or part.
AZOTEMIA - 1. <biochemistry> An excess in the blood of urea, creatinine and other nitrogenous end products of protein and amino acids metabolism, more correctly referred to as azotaemia. 2. <nephrology> In current usage the entire constellation of signs and symptoms of chronic renal failure including nausea, vomiting anorexia, a metallic taste in the mouth, a uraemic odour of the breath, pruritus, uraemic frost on the skin, neuromuscular disorders, pain and twitching in the muscles, hypertension, oedema, mental confusion and acid base and electrolyte imbalances.
BEHAVIOR DISORDER
BITING/CHEWING
BLEEDING:
    BLD
    BLD, ABDOMEN
    BLD, ANUS
    BLD, EYE(S)
    BLD, GI
    BLD(HEMATOMA)
    BLD, INCISION SITE
    BLD, LUNG(S)/TRACHEA
    BLD, MOUTH/LIP(S)
    BLD, RECTUM
    BLD, SCLERA
    BLD, SKIN
    BLD, VAGINA
BLOAT - 1. Abdominal distention from swallowed air or intestinal gas from fermentation. 2. Distention of the rumen of cattle, caused by the accumulation of gases of fermentation, particularly likely to occur when the animals are pastured on rich legume grasses; if unrelieved, the condition may quickly lead to death.
BORBORYGMI - <clinical sign> The rumbling, gurgling, tinkling noises heard on auscultation of the abdomen in conditions of increased intestinal peristalsis.
BREATHING ABN
BREATHING, DIFFICULT
CAT SCAN ABN
CELLULITIS
- <dermatology> An acute, diffuse, spreading, oedematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation. It is usually caused by infection of an operative or traumatic wound, burn or other cutaneous lesion by various bacteria, but group A streptococci and Staphylococcus aureus are the most common aetiological agents. cellulitis may also occur in immunocompromised hosts or it may follow erysipelas. It tends to spread to tissue spaces and cleavage planes owing to bacterial elaboration of large amounts of hyaluronidases that, break down polysaccharide ground substance, fibrinolysins that digest fibrin barriers and lecithinases that destroy cell membranes. Clinical manifestations include an area of oedema, warmth and tenderness with indistinct margins.
CHOLECYSTITIS
- <pathology, surgery> Acute or chronic inflammation of the gallbladder.
CIRCLING
COLLAPSE
CONFUSION
CONGESTION - Excessive or abnormal accumulation of blood in a part.
CONGESTION, EAR(S)
CONGESTION, EYE(S)/LID
CONGESTION, LUNG(S)
CONGESTION, MUCOUS MEM
CONGESTION, SINUS

CONSTIPATION - <gastroenterology> Infrequent or difficult evacuation of the faeces.
CONVULSION(S) - Seizures manifested by discontinuous involuntary skeletal muscular contractions, either brief contractions repeated at short intervals or longer ones interrupted by intervals of muscular relaxation. <disease, neurology> The paroxysmal transient disturbances of brain function that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances or perturbation of the autonomic nervous system. Symptoms are due to paroxysmal disturbance of the electrical activity of the brain. On the basis of origin, epilepsy is idiopathic (cryptogenic, essential, genetic) or symptomatic (acquired, organic). On the basis of clinical and electroencephalographic phenomenon, four subdivisions are recognised: 1. Grand mal epilepsy (major epilepsy, haut mal epilepsy) subgroups: generalised, focal (localised), jacksonian (rolandic)
COOMBS TEST POS - Haemagglutination test in which coombs' reagent (antiglobulin, or anti-human globulin rabbit immune serum) is added to detect incomplete (non-agglutinating, univalent, blocking) antibodies coating erythrocytes. The direct test is applied to red cells which have been coated with antibody in vivo (e.g., in haemolytic disease of newborn, autoimmune haemolytic anaemia, and transfusion reactions). The indirect test is applied to serum to detect the presence of antibody (e.g., in detection of incompatibility in cross-matching tests, detection and identification of irregular antibodies, and in detection of antibodies not identifiable by other means).
COUGHING
CYSTITIS - <pathology> Inflammation of the urinary bladder.
CYANOSIS
- <clinical sign> A bluish discolouration, applied especially to such discolouration of skin and mucous membranes due to excessive concentration of reduced haemoglobin in the blood.
DEAFNESS
DEAFNESS, TEMP
DEFECATION - <gastroenterology> To expel faeces from the rectum.
DEFECATION ABN

DEHISCENCE - A premature bursting open or splitting along natural or surgical suture lines. A complication of surgery that occurs secondary to poor wound healing. Risk factors include diabetes, advanced age, obesity and trauma during the post-surgical period.
DEHYDRATION - The condition that results from excessive loss of body water. Synonym: anhydration, deaquation, hypohydration.
DEMENTIA - <neurology, psychiatry> An organic mental disorder characterised by a general loss of intellectual abilities involving impairment of memory, judgment and abstract thinking as well as changes in personality. It does not include loss of intellectual functioning caused by clouding of consciousness (as in delirium) nor that caused by depression or other functional mental disorder (pseudodementia). Dementia may be caused by a large number of conditions, some reversible and some progressive, that cause widespread cerebral and damage or dysfunction. The most common cause is Alzheimer's disease, others are cerebrovascular disease (multi infarct dementia), central nervous system infection, brain trauma or tumours, pernicious anaemia, folic acid deficiency, Wernicke Korsakoff syndrome, normal pressure hydrocephalus, and, neurological diseases such as Huntington disease, multiple sclerosis and Parkinson's disease.
DEPRESSION/LETHARGY
DESTRUCTIVENESS
DIABETES MELLITUS - <disease> Relative or absolute lack of insulin leading to uncontrolled carbohydrate metabolism. In juvenile onset diabetes (that may be an autoimmune response to pancreatic _ cells) the insulin deficiency tends to be almost total, whereas in adult onset diabetes there seems to be no immunological component but an association with obesity.
DIARRHEA - <medicine> A morbidly frequent and profuse discharge of loose or fluid evacuations from the intestines, without tenesmus; a purging or looseness of the bowels; a flux.
DIARRHEA, BLOODY
DIARRHEA, MILD
DIARRHEA, MUCOID - MUCOID: Resembling mucus.
DIARRHEA, SEVERE
DIARRHEA, WATERY
DIC
- disseminated intravascular coagulation - <haematology> Complication of septic shock in which endotoxin (from gram-negative bacteria) induces systemic clotting of the blood, probably indirectly through the effect of endotoxin on neutrophils. It may also develop in other situations where neutrophils become systemically hyperactivated. Acronym: DIC
DIFFICULTY RISING
DISCHARGE, INCISION SITE
DISCHARGE, NOSE
DISCOMFORT
DISTENTION, ABDOMEN
DISTENTION, BLADDER
DISTRESS
DISTRESS, RESP
DYSPHAGIA
- <symptom> Difficulty in swallowing.
DYSPNEA - <symptom> Shortness of breath, difficult or laboured breathing.
DYSURIA - <symptom> Painful or difficult urination.
ECCHYMOSIS, INCISION SITE - <dermatology> A small haemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch.
EDEMA - <clinical sign> The presence of abnormally large amounts of fluid in the intercellular tissue spaces of the body, usually applied to demonstrable accumulation of excessive fluid in the subcutaneous tissues. Oedema may be localised, due to venous or lymphatic obstruction or to increased vascular permeability or it may be systemic due to heart failure or renal disease. Collections of oedema fluid are designated according to the site, for example ascites (peritoneal cavity), hydrothorax (pleural cavity) and hydropericardium (pericardial sac). Massive generalised oedema is called anasarca.
EDEMA, FEET/DIGIT(S)
EDEMA, HEAD/FACE
EDEMA, LARYNX
EDEMA, LIMB(S)
EDEMA, LUNG(S)/TRACHEA
EDEMA, VENTRAL
EFFUSION, JOINT(S) - EFFUSION: The escape of fluid into a part or tissue, as an exudation or a transudation. Origin: L. Effusio = a pouring out
EFFUSION, PERITONEAL
- PERITONEAL: <anatomy> Of or pertaining to the peritoneum. PERITONEUM: <anatomy> The smooth serous membrane which lines the cavity of the abdomen, or the whole body cavity when there is no diaphragm, and, turning back, surrounds the viscera, forming a closed, or nearly closed, sac.
EFFUSION, PLEURAL - <anatomy> Of or pertaining to the pleura or pleurae, or to the sides of the thorax. PLEURA: <anatomy> The serous membranes covering the lungs (visceral pleura) and lining the inner aspect of the pleural cavity (parietal pleura).
ELIMINATION ABN
ENLARGEMENT, LYMPH NOD
EPISTAXIS - <clinical sign> Nosebleed, haemorrhage from the nose.
ERUCTATION - <symptom> The act of belching or of casting up wind from the stomach through the mouth
ERUPTION(S) - 1. <dentistry> The act of breaking out, appearing or becoming visible, as eruption of the teeth. 2. <dermatology> Visible efflorescent lesions of the skin due to disease, especially an exanthematous disease and marked by redness and prominence, a rash.
EXERCISE INTOLERANCE

EYES/VISION:
    ABRASION, CORNEA(S) - CORNEA: <anatomy, ophthalmology> The transparent structure forming the anterior part of the fibrous tunic of the eye.
    BLINDNESS
    BLINDNESS, PARTIAL
    BLINDNESS, TEMP
    CONJUNCTIVITIS - <ophthalmology> Inflammation of the conjunctiva, generally consisting of conjunctival hyperaemia associated with a discharge
    DISCHARGE, EYE(S)/LID(S)
    EDEMA, CORNEA(S)
    EDEMA, EYE(S)/LID(S)
    EYE DISORDER
    GLAUCOMA - <ophthalmology> A group of eye diseases characterised by an increase in intraocular pressure which causes pathological changes in the optic disk and typical defects in the field of vision.
    INFECTION, EYE(S)
    IRRITATION, EYE(S)/LID
    KERATOCONJUNCTIVITIS S
- <ophthalmology> Inflammation of the cornea and conjunctiva.
    NYSTAGMUS - <neurology> An involuntary, rapid, rhythmic movement of the eyeball, which may be horizontal, vertical, rotatory or mixed, i.e., of two varieties.
    NYSTAGMUS, HORIZONTAL
    NYSTAGMUS, ROTARY
    NYSTAGMUS, VERTICAL
    OPACITY, CORNEA(S)
    PROLAPSE, THIRD EYELID - Hypertrophy and prolapse of the gland of the nictitating membrane (cherry eye) is common in young dogs. Prolapsed gland of  nictitating membrane, dog In the acute stage, the red mass swells and protrudes over the leading margin of the nictitans, and there is a mucopurulent discharge. Although the swelling may recede for short periods, it eventually often remains prolapsed.
    PROTRUSION, EYE(S)
    PUPIL(S), AREFLEXIA - AREFLEXIA:
Absence of reflexes
    PRURITIS, EYE(S)
    STRABISMUS - <
clinical sign> A deviation of the eye which the patient cannot overcome. The visual axes assume a position relative to each other different from that required by the physiological conditions. The various forms of strabismus are spoken of as tropias, their direction being indicated by the appropriate prefix, as cyclo tropia, esotropia, exotropia, hypertropia and hypotropia. Also called cast, heterotropia, manifest deviation and squint.
    SWELLING, EYE(S)/LID(S
    ULCER(S), CORNEA(S)
    VISION DISORDER
FEVER, BODY
FLATULENCE
FLY BITING - from Merck Veterinary Manual online: A specific type of seizure known as temporal lobe epilepsy appears to be familial in Cavalier King Charles Spaniels and is characterized by behavioral manifestations such as fly biting 
FROTH, MOUTH/LIP(S)
GAGGING
GALL BLADDER, ABN
GASTRITIS
- <pathology> Inflammation of the stomach.
GASTROENTERITIS
- <gastroenterology, pathology> An acute inflammation of the lining of the stomach and intestines, characterised by anorexia, nausea, diarrhoea, abdominal pain and weakness, which has various causes, including food poisoning due to infection with such organisms as Escherichia coli, Staphylococcus aureus and Salmonella species, consumption of irritating food or drink or psychological factors such as anger, stress and fear.
GI, ABNORMAL
GINGIVA, ABN -  - The gum.
GINGIVITIS
- <pathology> Inflammation of the gingivae
.
HAIR, ABN
HAIR, ABN COLOR
HAIR, SHEDDING
HEAD PRESSING
HEAD TILT
HEALING IMPAIRED
HEART-RELATED:
    ARREST, HEART
    ARRHYTHMIA - <cardiology, physiology> Any variation from the normal rhythm of the heart beat, including sinus arrhythmia, premature beat, heart block, atrial fibrillation, atrial flutter, pulsus alternans and paroxysmal tachycardia
    BRADYCARDIA - <clinical sign> A slowness of the heart beat, as evidenced by slowing of the pulse rate to less than 60 beats per minute
    CARDIOMEGALY
- <cardiology, clinical sign> Cardiac hypertrophy. HYPERTROPHY: The enlargement or overgrowth of an organ or part due to an increase in size of its constituent cells.
    ECG ABN - <cardiology, investigation> An recording of the electrical activity of the heart on a moving strip of paper. The electrocardiogram detects and records the electrical potential of the heart during contraction.
     HEART FAILURE
    MURMUR, HEART
    PRESSURE LO, BLD
    PULSE THREADY
    TACHYCARDIA
- <clinical sign> The excessive rapidity in the action of the heart, the term is usually applied to a heart rate above 100 per minute and may be qualified as atrial, junctional (nodal) or ventricular and as paroxysmal.
    TACHYCARDIA, VENTRICUL
HEPATITIS - <pathology> Inflammation of the liver.
HEMATOCHEZIA
- 1) Sorry, the term HEMATOCHEZIA is not in the dictionary  2) You Searched for: HEMATOCHEZIA: 0 results were found.
HEPATOMEGALY - <clinical sign> Enlargement of the liver.
HIDING
HORNER'S SYNDROME - <syndrome> A nerve condition which involves a dropping eyelid (ptosis), constricted pupil, enophthalmos and lack of sweating on one side of the face. Often seen in association with injury (for example neck fracture, penetrating injury) to the cervical sympathetic nerve trunk in the neck or a Pancoast tumour involving both the upper and lower brachial plexus.
HYPERACTIVITY
HYPERADRENOCORTICISM - Excess hormone called cortisol. Often called cushing's syndrome, it is an extremely complex condition that involves many areas of the body. It results from an excess of cortisol and its effects on the human body. Common symptoms are thinning of the skin, weakness, weight gain, bruising, hypertension, diabetes, weak bones (osteoporosis), facial puffiness, and in women cessation of periods. One of the commonest causes of cushing's syndrome is the administration of cortisol-like medications for the treatment of diverse diseases. All other cases of cushing's syndrome are due to excess production of cortisol by the adrenal gland including 1) an abnormal growth of the pituitary gland, which stimulates the adrenal gland, 2) a benign or malignant growth within the adrenal gland itself, which produces cortisol and 3) production within another part of the body (ectopic production) of a hormone that directly or indirectly stimulates the adrenal gland to make cortisol. Harvey cushing (1869-1939), a neurosurgeon, described hyperadrenocorticism due specifically to an acth-secreting basophilic pituitary adenoma, a benign pituitary tumour that puts out acth (adrenocorticotropic hormone) that, in turn, drives (or overdrives) the adrenal gland.
HYPERESTHESIA - <neurology, physiology> A neurologic symptom where there is an unusual increased or altered sensitivity to sensory stimuli.
HYPERMOTILITY - 1) Sorry, the term HYPERMOTILITY is not in the dictionary. 2) You Searched for: HYPERMOTILITY: 0 results were found.
HYPERPNEA
- Breathing which is deeper and more rapid than expected.
HYPERSALIVATION
HYPERSENSITIVE, SOUND
HYPHEMA -Haemorrhage within the anterior chamber of the eye
HYPOADRENOCORTICISM
- 1) Sorry, the term HYPOADRENOCORTICISM is not in the dictionary 2) You Searched for: HYPOADRENOCORTICISM: 0 results were found.
HYPOPNEA - Breathing that is shallower, and/or slower, than normal.
HYPOTHERMIA - 1) <physiology> A low body temperature, as that due to exposure in cold weather or a state of low temperature of the body induced as a means of decreasing metabolism of tissues and thereby the need for oxygen, as used in various surgical procedures, especially on the heart or in an excised organ being preserved for transplantation. 2) When the skin or blood is cooled enough to lower the body temperature in nonhibernating animals, metabolic and physiological processes slow. Respiration and heart rate are slow, blood pressure is low, and consciousness is lost. At a rectal temperature of <82°F (28°C), the ability to regain normal temperature is lost, but the animal will survive if external heat is applied and the temperature returns to normal. These findings have been adapted and used extensively in heart and brain surgery in man. In hypothermic states, the oxygen need of cells, particularly neurons, is greatly reduced, and the circulation can be stopped for relatively long periods. A lowered body temperature is seen in moribund states. It is a poor prognostic sign in infectious diseases. In accidental hypothermia, the animal should be brought into a heated environment and allowed to warm slowly to its normal temperature.
HYPOTHERMIA, BODY
INCISION SITE ABN
INCISION SITE DISCHARGE
ICTERUS - <clinical sign> The presence of jaundice seen in the sclera of the eye.
ICTERUS, BODY
ICTERUS, SERUM
IMMUNE DISORDER

INCISION SITE INFECTION
INCONTINENCE
INCONTINENCE, FECAL
INCONTINENCE, URINARY
INEFFECT, ANALGESIA
INFECTION, INCISION SITE
INFECTION, URINARY TRA
INFLAM, SKIN
INEFFECT, ANTIINFLAM
INEFFECT, LOSS OF EFFE
INTERACTION, DRUG(S)
INSOMNIA
KETOSIS -
<biochemistry> Metabolic production of abnormal amounts of ketones. A consequence of diabetes melittus.
KIDNEY DISORDER
KIDNEY FAILURE
LABORATORY/BLOOD TESTS:
    A/G RATIO LO, BLD
    ALBUMIN HI, BLD
    ALBUMIN LO, BLD
    ALK PHOS HI, BLD
    AMYLASE HI, BLD
    ANION GAP HI, BLD
    BANDS HI, BLD
    BASOS HI, BLD
    BILE ACIDS HI, BLD
    BILIRUBIN(DIR) HI, BLD
    BILIRUBIN(TOT) HI, BLD
    BUN HI, BLD
    BUN LO, BLD
    CA HI, BLD
    CA LO, BLD
    CAPILLARY REFILL PROLO
    CHEMISTRY ABN
    CHLORIDE HI, BLD
    CHLORIDE LO, BLD
    CHOLESTEROL HI, BLD
    CHOLESTEROL LO, BLD
    CO2 LO, BLD
    COAGULATION DISORDER
    CPK HI, BLD
    CREATININE HI, BLD
    CULTURE/TITER DATA ABN
    EOSINOS HI, BLD
    EOSINOS LO, BLD
    GGT HI, BLD
    GLOBULIN HI, BLD
    GLOBULIN LO, BLD
    GLUCOSE HI, BLD
    GLUCOSE LO, BLD
    K HI, BLD
    K LO, BLD
    KIDNEY VALUES HI, BLD
    LDH HI, BLD
    LIPASE HI, BLD
    LIVER ENZYMES HI, BLD
    LYMPHS HI, BLD
    LYMPHS LO, BLD
    MG HI, BLD
    MG LO, BLD
    MONOS HI, BLD
    NA HI, BLD
    NA LO, BLD
    NA:K LO, BLD
    P HI, BLD
    P LO, BLD
    PANCREAS ENZYMES HI, B
    PLATELETS HI, BLD
    PLATELETS LO, BLD
    PROTEIN(TOT) HI, BLD
    PROTEIN(TOT) LO, BLD
    PT PROLONGED, BLD
    PTT PROLONGED, BLD
    RBC ABN
    RBC, NUCLEATED
    RETICULOCYTES HI, BLD
    RETICULOCYTES LO, BLD
    SEGS HI, BLD
    SEGS LO, BLD
    SGOT/AST HI, BLD
    SGPT/ALT HI, BLD
    THYROID HORMONE(S) HI
    THYROID HORMONE(S) LO
    TRIGLYCERIDES HI, BLD
    WBC HI, BLD
    WBC LO, BLD
LABORATORY/URINE TESTS:
    ABN COLOR, URINE
    ACID URINE
    ALBUMIN HI, URINE
    ALKALINE URINE
    BILIRUBIN, URINE
    BLD, URINE
    CALCULI, BLADDER
    CASTS, URINE
    CORT/CREAT HI, URINE
    CRYSTALS, URINE
    GLUCOSE, URINE
    HEMOGLOBIN, URINE
    MICROORANISMS, URINE
    PROTEIN, URINE
    SPEC GRAVITY LO, URINE
    WBC, URINE
LAMENESS
LICKING
LICKING, FEET/DIGIT(S)
LIVER DISORDER
LIVER FAILURE
LOCOMOTION DISORDER
MASS
MASS, ABDOMEN
MASS, SKIN
MELENA - 1. <gastroenterology> The passage of dark, pitchy and grumous stools stained with blood pigments or with altered blood. 2. Black vomit.
MIOSIS - <physiology> Contraction of the pupils.
MORIBUND -
In a dying state; dying; at the point of death. "The patient was comatose and moribund." (Copland
MRI SCAN ABN
MUCOUS MEMBR, MUDDY - MUCOUS MEMBRANE: <pathology> The lubricated inner lining of the mouth, nasal passages, vagina and urethra, any membrane or lining which contains mucous secreting glands.
MUCOUS MEMBR, RED

MYDRIASIS - <medicine> A long-continued or excessive dilatation of the pupil of the eye.
NAUSEA
NECK, VENTROFLEXION - Sorry, the term VENTROFLEXION is not in the dictionary
NECROSIS
-<pathology> The sum of the morphological changes indicative of cell death and caused by the progressive degradative action of enzymes, it may affect groups of cells or part of a structure or an organ. Origin: Gr. Nekrosis = deadness
NEOPLASM - <oncology, pathology> New and abnormal growth of tissue, which may be benign or cancerous.
NEOPLASM, LIVER
NEOPLASM, LYMPH NODE(S
NEOPLASM, MULT SITES
NEOPLASM, SPLEEN
NERVOUSNESS
NEURITIS - <clinical sign> Inflammation of a nerve, a condition attended by pain and tenderness over the nerves, anaesthesia and paraesthesias, paralysis, wasting and disappearance of the reflexes. In practice, the term is also used to denote noninflammatory lesions of the peripheral nervous system. If the involvement is in one nerve it is called mononeuritis, in several nerves, mononeuritis multiplex, if diffuse and bilateral, polyneuritis.
NEUROLOGICAL DISORDER
- Neurologic symptoms can be variable. Examples include: numbness, tingling, hyperesthesia (increased sensitivity), paralysis, localised weakness, dysarthria (difficult speech), aphasia (inability to speak), dysphagia (difficulty swallowing), diplopia (double vision), amaurosis fugax (temporary loss of vision in one eye) difficulty walking, incoordination, tremor, seizures, confusion, lethargy, dementia, delirium and coma. All the above can be symptoms of stroke.
NOSE ABN
ODOR, MOUTH

OLIGURIA - <nephrology, physiology> Secretion of a diminished amount of urine in relation to the fluid intake.
OTITIS - <pathology> Inflammation of the ear, which may be marked by pain, fever, abnormalities of hearing, hearing loss, tinnitus and vertigo.
PACING
PAIN
PAIN, ABDOMEN
PAIN, NECK
PALLOR
PALLOR, MUCOUS MEMBRAN
PANCREAS DISORDER
PANCREATITIS - <gastroenterology, surgery> Acute or chronic inflammation of the pancreas, which may be asymptomatic or symptomatic and which is due to autodigestion of a pancreatic tissue by its own enzymes. It is caused most often by alcoholism or biliary tract disease, less commonly it may be associated with hyperlipaemia, hyperparathyroidism, abdominal trauma (accidental or operative injury), vasculitis or uraemia.
PARALYSIS - <neurology> Loss or impairment of motor function in a part due to lesion of the neural or muscular mechanism, also by analogy, impairment of sensory function (sensory paralysis). In addition to the types named below, paralysis is further distinguished as traumatic, syphilitic, toxic, etc., according to its cause or as obturator, ulnar, etc., according to the nerve part or muscle specially affected.
PARALYSIS, FACIAL NERV
PARALYSIS, HIND LIMB(S
PARESIS
- <neurology> Slight or incomplete paralysis.
PARESIS, HIND LIMB(S)
PAWING
PERFORATION - 1. The act of boring or piercing through a part. 2. A hole made through a part or substance.
PERFORATION, GI
PERFORATION, STOMACH
PERITONITIS - <pathology> Inflammation of the peritoneum, a condition marked by exudations in the peritoneum of serum, fibrin, cells and pus. It is attended by abdominal pain and tenderness, constipation, vomiting and moderate fever.
PICA - <medicine> A vitiated appetite that craves what is unfit for food, as chalk, ashes, coal, etc
PNEUMONIA - <chest medicine> Inflammation of the lungs with consolidation.
PNEUMONIA, ASPIRATION
- Inflammation of the lungs due to aspiration (the sucking in of food particles or fluids into the lungs).
POLLAKIURIA - Rarely used term for extraordinary urinary frequency.
POLYCYTHEMIA - The opposite of anaemia. Too many red blood cells. Polycythemia formally exists when the haemoglobin, red blood cell count, and total rbc volume are all above normal.
POLYCYTHEMIA(RELATIVE) - 1) Sorry, the term POLYCYTHEMIA(RELATIVE) is not in the dictionary. 2) POLYCYTHEMIA: The opposite of anaemia. Too many red blood cells. Polycythemia formally exists when the haemoglobin, red blood cell count, and total rbc volume are all above normal.
POLYDIPSIA -<symptom> Chronic excessive thirst, as in diabetes mellitus or diabetes insipidus
POLYPHAGIA - <symptom> Great hunger, a sign of diabetes. People with this great hunger often lose weight.
POLYPNEA - 1) Synonym: tachypnea. TACHYPNEA: An abnormally rapid (usually shallow) respiratory rate.
POLYURIA - <symptom> The passage of a large volume of urine in a given period, a characteristic of diabetes.
PD-TABLET(S), ABN
PR-ADRENAL(S), LESION(S)
PR-BLADDER, LESION(S)
PR-BONE MARROW, LESION
PR-BRAIN, LESION(S)
PR-COLON, LESION(S)
PR-ESOPHAGUS, LESION(S
PR-GALL BLADDER, LESION(S)
PR-GI, LESION(S)
PR-HEART, LESION(S)
PR-HEARTWORM DISEASE
PR-INTEST, LESION(S)
PR-KIDNEY(S), LESION(S
PR-LIVER, LESION(S)
PR-LUNG(S), EDEMA
PR-LUNG(S), LESION(S)
PR-LYMPH NODE(S), LESI
PR-MOUTH/LIP(S), LESIO
PR-NOSE, LESION(S)
PR-PANCREAS, LESION(S)
PR-PERICARDIAL EFFUSIO
PR-PERITONEAL EFFUSION
PR-PERITONEUM, LESION(
PR-SKIN, LESION(S)
PR-SM INTEST, LESION(S)
PR-SPLEEN, LESION(S)
PR-STOMACH, LESION(S)
PROPRIOCEPTIVE DISORDE - <physiology> Capable of receiving stimuli originating in muscles, tendons, and other internal tissues.
PROSTATOMEGALY - Enlargement of the prostate gland.
PRURITIS - Itching. Pruritis can result from drug reaction, food allergy, kidney or liver disease, cancers, parasites, aging or dry skin, contact skin reaction, such as poison ivy, and for unknown reasons.
PRURITIS, EAR(S)
PRURITIS, EYE(S)
PRURITIS, FEET/DIGIT(S
RADIOGRAPH(S) ABN
RECUMBENCY - 1) Sorry, the term RECUMBENCY is not in the dictionary.  2) 0 results were found. 3) Websters: Main Entry: re·cum·ben·cy Pronunciation: ri-'k&m-b&n(t)-sE Function: noun Inflected Form(s):  plural -cies Date: 1646
: the state of leaning, resting, or reclining : REPOSE; also : a recumbent position
REFLEX(ES) ABN
REGURGITATION
REGURGITATION, FOOD
RELUCTANT TO MOVE
RESPIRATORY DISORDER

ROLLING
SEPTICEMIA
- Systemic disease associated with the presence and persistence of pathogenic microorganisms or their toxins in the blood. Synonym: blood poisoning.
SEPSIS - The presence of organisms in the blood. SEPSIS SYNDROME: <syndrome> A systemic response to infection, defined as hypothermia or hyperthermia, tachycardia, tachypnea, a clinically evident focus of infection or positive blood cultures, one or more end organs with either dysfunction or inadequate perfusion, cerebral dysfunction, hypoxaemia, increased plasma lactate or unexplained metabolic acidosis, and oliguria. It is one of the most common causes of adult respiratory distress syndrome. While usually related to infection, it can also be associated with noninfectious insults such as trauma, burns, pancreatitis.
SHAKING
SHOCK
- <cardiology> A condition of profound haemodynamic and metabolic disturbance characterised by failure of the circulatory system to maintain adequate perfusion of vital organs, it may result from inadequate blood volume (hypovolaemic shock), inadequate cardiac function (cardiogenic shock) or inadequate vasomotor tone (neurogenic shock, septic shock).
SHOCK, ENDOTOXEMIA - ENDOTOXIC SHOCK: Shock induced by release of endotoxin from Gram-negative bacteria, especially by Escherichia coli.
SLOUGH, TONGUE
- SLOUGHING: <zoology> The act of casting off the skin or shell SLOUHING ULCER: <dermatology> A rapidly spreading ulcer attended by the formation of extensive sloughing.
SKIN:
     ABSCESS, SKIN - <microbiology, surgery> A localised collection of pus caused by suppuration buried in tissues, organs or confined spaces. Usually due to an infective process.
    ALOPECIA - 1. <dermatology> Baldness, absence of the hair from skin areas where it normally is present. 2. <oncology> Hair loss as a result of chemotherapy or radiation therapy administered to the head. Hair loss from chemotherapy is temporary. Hair loss from radiation is usually permanent.
    BLD(ECCHYMOSES) - Sorry, the term ECCHYMOSES is not in the dictionary; ECCHYMOSIS: <dermatology> A small haemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch.
    BLD(PETECHIAE) - Small red spots on the skin that usually indicate a low platelet count.
    CONGESTION, SKIN
   ENLARGEMENT(S), SKIN
    ERYTHEMA MULTIFORME - <dermatology> A rash that results from an allergic response, most often secondary to a drug. The rash is described as pink-red macules (flat), that may have clear centres (iris lesions) or appear as a dusky violet colour. Erythema multiforme most often results from reactions to sulpha drugs, penicillin's, phenytoin, barbiturates, phenolphthalein and carbamazepine. In some cases, erythema multiforme can result secondary to a Herpes simplex infection or Mycoplasma infection.
    HYPERPIGMENTATION, SKI - Darkening of the skin.
    
INFECTION, SKIN
   LESION(S), SKIN - <pathology> Any pathological or traumatic discontinuity of tissue or loss of function of a part.
    PAPULE(S) - <dermatology> A small circumscribed, superficial, solid elevation of the skin.
   PUSTULE(S) - <medicine> A vesicle or an elevation of the cuticle with an inflamed base, containing pus.
   RASH
    SCALE(S), SKIN
   SEBORRHEA
- <medicine> A morbidly increased discharge of sebaceous matter upon the skin
    SKIN, CRUST(S)
   SKIN, NECROSIS
- <pathology> The sum of the morphological changes indicative of cell death and caused by the progressive degradative action of enzymes, it may affect groups of cells or part of a structure or an organ
    
SKIN, SCAB(S)
   SLOUGH, SKIN
   ULCER(S), SKIN
   VESICLE(S)/BULLAE, SKI - VESICLE: <pathology> A closed membrane shell, derived from membranes either by a physiological process (budding) or mechanically by sonication. BULLAE: The pleural of bulla. BULLA: <medicine> A bleb; a vesicle, or an elevation of the cuticle, containing a transparent watery fluid.
SNEEZING
SOUND ABN, RESPIRATORY
SPASM - <physiology> A sudden, violent, involuntary contraction of a muscle or a group of muscles, attended by pain and interference with function, producing involuntary movement and distortion.
SPLENOMEGALY
- <clinical sign> Enlargement of the spleen.
STAGGERING
STARING
STIFFNESS
STIFFNESS, FRONT LIMB(
STIFFNESS, HIND LIMB(S
STIFFNESS, LIMB(S)
STIFFNESS, NECK

STOMATITIS - <pathology> Inflammation of the oral mucosa, due to local or systemic factors which may involve the buccal and labial mucosa, palate, tongue, floor of the mouth and the gingivae.
STOOL ABN
STOOL, MUCOID
STRANGURIA - 1) Sorry, the term STRANGURIA is not in the dictionary. STRANGURY: <medicine> A painful discharge of urine, drop by drop, produced by spasmodic muscular contraction. 2) STRANGURIA: Disorders of micturition can result from any dysfunction in urine storage or voiding, which may be neurologic or non-neurologic in origin. Urinary incontinence is the failure of voluntary control of the urethral sphincter, with constant or intermittent unconscious passage of urine. Incontinent animals may leave a pool of urine where they have been lying or may dribble urine while walking. The coat around the vulva or prepuce may be wet, and perivulvar or peripreputial dermatitis can occur as the result of urine scalding.
STUMBLING
STUPOR - <neurology> The partial or nearly complete unconsciousness, manifested by the subject's responding only to vigorous stimulation.
SWELLING
SWELLING, FEET/DIGIT(S
SWELLING, HEAD/FACE
SWELLING, JOINT(S)
SWELLING, LIMB(S)

SYNCOPE - <clinical sign> A temporary suspension of consciousness due to generalised cerebral ischaemia, a faint or swoon.
TENESMUS - <symptom> Straining, especially ineffectual and painful straining at stool or in urination.
TENESMUS, RECTAL
THRASHING/PADDLING
TONGUE, ABN

TORTICOLLIS - <neurology> A wry neck, a contracted state of the cervical muscles, producing twisting of the neck and an unnatural position of the head.
TREMBLING
TREMBLING, FACE
TWITCH
ULCER(S), EAR(S)
ULCER(S), FEET/DIGIT(S
ULCER(S), GI
ULCER(S), MOUTH/LIP(S)
ULCER(S), MUCOCUTANEOU
ULCER(S), PYLORUS
ULCER(S), STOMACH
ULCER(S), TONGUE
UNCONSCIOUS
UNPALATABLE, WON'T EAT
URINATION
URINATION ABN

URTICARIA - <dermatology> A transient condition of the skin, usually caused by an allergic reaction, characterised by pale or reddened irregular, elevated patches and severe itching, hives.
US ABN
US-LIVER ABN
UVEITIS - <pathology> An inflammation of part or all of the uvea, the middle (vascular) tunic of the eye and commonly involving the other tunics (the sclera and cornea and the retina).
VESICLE(S)/BULLAE, MOU
- VESICLE: <pathology> A closed membrane shell, derived from membranes either by a physiological process (budding) or mechanically by sonication. BULLAE: The pleural of bulla. BULLA: <medicine> A bleb; a vesicle, or an elevation of the cuticle, containing a transparent watery fluid.
VESTIBULAR DISORDER
- VESTIBULAR DISEASES: Diseases of the vestibule, the part of the inner ear that contains organs involved with balance.
VOCALIZATION - 1) Vocal sounds used in animal communication. 2) 0 results were found. 3) Websters: 1 : to give voice to : UTTER; specifically : SING 2 a : to make voiced rather than voiceless : VOICE b : to convert to a vowel 3 : to furnish (as a consonantal Hebrew or Arabic text) with vowels or vowel points - intransitive senses 1 : to utter vocal sounds - 2 : SING; specifically : to sing without words - - vo·cal·i·za·tion /"vO-k&-l&-'zA-sh&n/ noun
VOICE DISORDER
VOLVULUS - <medicine> The spasmodic contraction of the intestines which causes colic. Any twisting or displacement of the intestines causing obstruction
VOLVULUS, STOMACH
VOMITING
VOMITING, BLOODY
VOMITING, SEVERE
VOMITING, UNPRODUCTIVE
WEAKNESS
WEIGHT INCREASE
WEIGHT LOSS
WHEEZING



May my beloved partner ROMI rest in peace  - no matter wherever her bits and pieces/frozen carcass may be held hostage.

                            

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